abstract：BACKGROUND:Despite advances in supportive care, moderate-severe acute respiratory distress syndrome (ARDS) is associated with high mortality rates, and novel therapies to treat this condition are needed. Compelling pre-clinical data from mouse, rat, sheep and ex vivo perfused human lung models support the use of human ...

journal_title：Annals of intensive care

authors： Liu KD,Wilson JG,Zhuo H,Caballero L,McMillan ML,Fang X,Cosgrove K,Calfee CS,Lee JW,Kangelaris KN,Gotts JE,Rogers AJ,Levitt JE,Wiener-Kronish JP,Delucchi KL,Leavitt AD,McKenna DH,Thompson BT,Matthay MA

更新日期：2014-07-03 00:00:00

abstract：:Anemia and red blood cell (RBC) transfusion occur frequently in hospitalized patients with cardiac disease. In this narrative review, we report the epidemiology of anemia and RBC transfusion in hospitalized adults and children (excluding premature neonates) with cardiac disease, and on the outcome of anemic and transf...

journal_title：Annals of intensive care

authors： Du Pont-Thibodeau G,Harrington K,Lacroix J

更新日期：2014-06-02 00:00:00

abstract：BACKGROUND:The Lung Injury Score (LIS) remains a commonly utilized measure of lung injury severity though the additive value of LIS to predict ARDS outcomes over the recent Berlin definition of ARDS, which incorporates severity, is not known. METHODS:We tested the association of LIS (in which scores range from 0 to 4,...

journal_title：Annals of intensive care

authors： Kangelaris KN,Calfee CS,May AK,Zhuo H,Matthay MA,Ware LB

更新日期：2014-02-18 00:00:00

abstract：BACKGROUND:Acute lung injury and the acute respiratory distress syndrome (ALI/ARDS) are characterized by pulmonary oedema, measured as extravascular lung water (EVLW). The chest radiograph (CXR) can potentially estimate the quantity of lung oedema while the transpulmonary thermodilution method measures the amount of EV...

journal_title：Annals of intensive care

authors： Brown LM,Calfee CS,Howard JP,Craig TR,Matthay MA,McAuley DF

更新日期：2013-08-11 00:00:00

abstract：:Pharmacological interventions are commonly considered in acute respiratory distress syndrome (ARDS) patients. Inhaled nitric oxide (iNO) and neuromuscular blockers (NMBs) are used in patients with severe hypoxemia. No outcome benefit has been observed with the systematic use of iNO. However, a sometimes important impr...

journal_title：Annals of intensive care

authors： Roch A,Hraiech S,Dizier S,Papazian L

更新日期：2013-07-03 00:00:00

abstract：: Human serum albumin (HSA) has been used for a long time as a resuscitation fluid in critically ill patients. It is known to exert several important physiological and pharmacological functions. Among them, the antioxidant properties seem to be of paramount importance as they may be implied in the potential beneficial ...

journal_title：Annals of intensive care

authors： Taverna M,Marie AL,Mira JP,Guidet B

更新日期：2013-02-15 00:00:00

abstract：: Red blood cells (RBC) storage facilitates the supply of RBC to meet the clinical demand for transfusion and to avoid wastage. However, RBC storage is associated with adverse changes in erythrocytes and their preservation medium. These changes are responsible for functional alterations and for the accumulation of pote...

journal_title：Annals of intensive care

authors： Aubron C,Nichol A,Cooper DJ,Bellomo R

更新日期：2013-01-15 00:00:00

abstract：UNLABELLED: BACKGROUND:A history of prolonged and excessive consumption of alcohol increases the risk for infections. The goal of this study was to investigate circulating white blood cells (WBC) differentiated by flow cytometry and neutrophil CD64 expression in excessive alcohol drinkers versus abstinent or moderate ...

journal_title：Annals of intensive care

authors： Gacouin A,Roussel M,Gros A,Sauvadet E,Uhel F,Chimot L,Marque S,Camus C,Fest T,Le Tulzo Y

更新日期：2012-12-31 00:00:00

abstract：: Thrombocytopenia is a very frequent disorder in the intensive care unit. Many etiologies should be searched, and therapeutic approaches differ according to these different causes. However, no guideline exists regarding optimum practices for these situations in critically ill patients. We present recommendations for t...

journal_title：Annals of intensive care

authors： Van der Linden T,Souweine B,Dupic L,Soufir L,Meyer P

更新日期：2012-08-28 00:00:00

abstract：INTRODUCTION:Capillary leak in critically ill patients leads to interstitial edema. Fluid overload is independently associated with poor prognosis. Bedside measurement of intra-abdominal pressure (IAP), extravascular lung water index (EVLWI), fluid balance, and capillary leak index (CLI) may provide a valuable prognost...

journal_title：Annals of intensive care

authors： Cordemans C,De Laet I,Van Regenmortel N,Schoonheydt K,Dits H,Huber W,Malbrain ML

更新日期：2012-07-05 00:00:00

abstract：BACKGROUND:The importance of intra-abdominal pressure (IAP) and abdominal perfusion pressure (APP) in cirrhotic patients with septic shock is not well studied. We evaluated the relationship between IAP and APP and outcomes of cirrhotic septic patients, and assessed the ability of these measures compared to other common...

journal_title：Annals of intensive care

authors： Al-Dorzi HM,Tamim HM,Rishu AH,Aljumah A,Arabi YM

更新日期：2012-07-05 00:00:00

abstract：: Cancer is a leading cause of death in children. In the past decades, there has been a marked increase in overall survival of children with cancer. However, children whose treatment includes hematopoietic stem cell transplantation still represent a subpopulation with a higher risk of mortality. These improvements in m...

journal_title：Annals of intensive care

authors： Demaret P,Pettersen G,Hubert P,Teira P,Emeriaud G

更新日期：2012-06-12 00:00:00

abstract：BACKGROUND:Hyponatremia occurring as a result of the syndrome of inappropriate antidiuretic hormone secretion (SIADH) or cerebral salt wasting syndrome is a common complication in patients with subarachnoid hemorrhage (SAH). The efficacy and safety of urea as treatment for SIADH-induced hyponatremia has not been report...

journal_title：Annals of intensive care

authors： Pierrakos C,Taccone FS,Decaux G,Vincent JL,Brimioulle S

更新日期：2012-05-30 00:00:00

abstract：: Critically ill adult patients often require multiple examinations in the hospital and need transport from one department to another, or even between hospitals. However, to date, no guidelines exist regarding optimum practices for transport of these fragile patients. We present recommendations for intrahospital transp...

journal_title：Annals of intensive care

authors： Quenot JP,Milési C,Cravoisy A,Capellier G,Mimoz O,Fourcade O,Gueugniaud PY

更新日期：2012-02-03 00:00:00

abstract：: Erythropoietin (EPO) is the major hormone stimulating the production and differentiation of red blood cells. EPO is used widely for treating anemia of critical illness or anemia induced by chemotherapy. EPO at pharmacological doses is used in this setting to raise hemoglobin levels (by preventing the apoptosis of ery...

journal_title：Annals of intensive care

authors： Patel NS,Collino M,Yaqoob MM,Thiemermann C

更新日期：2011-09-23 00:00:00

abstract：: Multiple experimental and human trials have shown that microcirculatory alterations are frequent in sepsis. In this review, we discuss the characteristics of these alterations, the various mechanisms potentially involved, and the implications for therapy. Sepsis-induced microvascular alterations are characterized by ...

journal_title：Annals of intensive care

authors： De Backer D,Donadello K,Taccone FS,Ospina-Tascon G,Salgado D,Vincent JL

更新日期：2011-07-19 00:00:00

abstract：: Microbiologists have extensively worked during the past decade on a particular phase of the bacterial cell cycle known as biofilm, in which single-celled individuals gather together to form a sedentary but dynamic community within a complex structure, displaying spatial and functional heterogeneity. In response to th...

journal_title：Annals of intensive care

authors： Bordi C,de Bentzmann S

更新日期：2011-06-13 00:00:00